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Icatibant

Chemical Structure : Icatibant

CAS No.: 130308-48-4

Icatibant (HOE-140;JE-049)

Catalog No.: PC-45267Not For Human Use, Lab Use Only.

Icatibant (HOE-140, JE-049) is a potent, selective and specific antagonist of bradykinin B2 receptor (B2R) with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

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Biological Activity

Icatibant (HOE-140, JE-049) is a potent, selective and specific antagonist of bradykinin B2 receptor (B2R) with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
Icatibant (HOE-140, JE-049) protects against memory impairment in mLFPI mice (10 nmol/kg).
Icatibant (HOE-140, JE-049) attenuates the brain edema, interleukin-1β, tumor necrosis factor-α, and nitric oxide metabolites content elicited by mLFPI.

Physicochemical Properties

M.Wt 1304.522
Formula C59H89N19O13S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-

References

1. Hock FJ, et al. Br J Pharmacol. 1991 Mar;102(3):769-73.

2. Ferreira AP, et al. Psychopharmacology (Berl). 2014 May;231(9):1935-48.

3. Asghar AU, et al. Eur J Pharmacol. 2000 Jun 9;398(1):131-8.

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