Imetelstat | Telomerase inhibitor | Probechem Biochemicals

Chemical Structure : Imetelstat

Imetelstat (GRN163L)

Catalog No.: PC-22757Not For Human Use, Lab Use Only.

Imetelstat (GRN163L) is a first-in-class, lipid-conjugated N3'→P5' thio-phosphoramidate oligonucleotide telomerase inhibitor with IC50 of 0.45 uM, blocks the template region of telomerase.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Imetelstat (GRN163L) is a first-in-class, lipid-conjugated N3'→P5' thio-phosphoramidate oligonucleotide telomerase inhibitor with IC50 of 0.45 uM, blocks the template region of telomerase.

Physicochemical Properties

M.Wt	4610.18
Formula	C148H211N68O53P13S13
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-amino-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinoth

References

1. Marian CO, et al. Clin Cancer Res. 2010 Jan 1;16(1):154-63.

2. Burchett KM, et al. PLoS One. 2014 Jan 7;9(1):e85155.

Imetelstat (GRN163L)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.