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Imifoplatin

Chemical Structure : Imifoplatin

CAS No.: 1339960-28-9

Imifoplatin (PT-112)

Catalog No.: PC-25340Not For Human Use, Lab Use Only.

Imifoplatin (PT-112) is the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, is an immunogenic cell death (ICD)-inducing small molecule, inhibits ribosome biogenesis and causes organelle stresses, leading to selective ICD in cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Imifoplatin (PT-112) is the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, is an immunogenic cell death (ICD)-inducing small molecule, inhibits ribosome biogenesis and causes organelle stresses, leading to selective ICD in cancer cells.

Physicochemical Properties

M.Wt 485.23
Formula C6H16N2O7P2Pt
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Yamazaki T, et al. Oncoimmunology. 2020 Feb 11;9(1):1721810.

2. Karp DD, et al. EClinicalMedicine. 2022 May 27;49:101430.

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