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Imigliptin dihydrochloride

Chemical Structure : Imigliptin dihydrochloride

CAS No.: 1314944-07-4

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Imigliptin dihydrochloride (Imigliptin, KBP-3853, KBP3853)

Catalog No.: PC-60064Not For Human Use, Lab Use Only.

Imigliptin dihydrochloride (KBP-3853) is a potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Imigliptin dihydrochloride (KBP-3853) is a potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.
    Imigliptin dihydrochloride (KBP-3853) displays no activity against DPP-8 and DPP-9 (IC50>100 uM).
    Imigliptin dihydrochloride (KBP-3853) shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell.

    Physicochemical Properties

    M.Wt 449.38
    Formula C21H26Cl2N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-((7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)methyl)benzonitrile dihydrochloride

    References

    1. Shu C, et al. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6.

    2. Liu D, et al. Eur J Pharm Sci. 2016 Jun 30;89:73-82.

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