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Chemical Structure : Imigliptin dihydrochloride
Catalog No.: PC-60064Not For Human Use, Lab Use Only.
Imigliptin dihydrochloride (KBP-3853) is a potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.
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Imigliptin dihydrochloride (KBP-3853) is a potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.
Imigliptin dihydrochloride (KBP-3853) displays no activity against DPP-8 and DPP-9 (IC50>100 uM).
Imigliptin dihydrochloride (KBP-3853) shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell.
| M.Wt | 449.38 | |
| Formula | C21H26Cl2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shu C, et al. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6.
2. Liu D, et al. Eur J Pharm Sci. 2016 Jun 30;89:73-82.
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