Imigliptin dihydrochloride (KBP-3853) is a potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.
Imigliptin dihydrochloride (KBP-3853) displays no activity against DPP-8 and DPP-9 (IC50>100 uM).
Imigliptin dihydrochloride (KBP-3853) shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell.
