Imisopasem manganese |CAS:218791-21-0 Probechem Biochemicals

Chemical Structure : Imisopasem manganese

CAS No.: 218791-21-0

Imisopasem manganese (M-40403;GC-4419)

Catalog No.: PC-43504Not For Human Use, Lab Use Only.

A small-molecule superoxide dismutase (SOD) mimetic that converts superoxide to hydrogen peroxide and molecular oxygen.

Packing	Price	Stock
5 mg	$120	In stock
10 mg	$192	In stock
25 mg	$360	In stock
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Biological Activity

A small-molecule superoxide dismutase (SOD) mimetic that converts superoxide to hydrogen peroxide and molecular oxygen; significantly mitigates the increased sensitivity of old fibroblasts to ionizing radiation and chemotherapy and partially restores mitochondrial function without affecting ionizing radiation or chemotherapy-induced cancer cell killing.

Chemotherapeutic Agents

Phase 2 Clinical

Physicochemical Properties

M.Wt	479.348385
Formula	C21H31Cl2MnN5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	H2O: 16 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	Manganese, dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7H-dibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-κN5,κN13,κN18,κN21,κN22]-, (PB-7-11-2344'3')-

References

1. Tuder RM, et al. Am J Respir Cell Mol Biol. 2003 Jul;29(1):88-97.

2. Mapuskar KA, et al. Cancer Res. 2017 Aug 1. pii: canres.0106.2017.

Imisopasem manganese (M-40403;GC-4419)

Biological Activity

Physicochemical Properties

References

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