Importazole | Importin β inhibitor | Probechem Biochemicals

Chemical Structure : Importazole

CAS No.: 662163-81-7

Importazole (Importin β inhibitor)

Catalog No.: PC-42312Not For Human Use, Lab Use Only.

Importazole is a specific, cell permeable transport receptor Importin-β inhibitor that disrupts Ran GTP/importin-β interaction.

Packing	Price	Stock
10 mg	$68	In stock
25 mg	$98	In stock
50 mg	$158	In stock
100 mg	$258	In stock
250 mg		Get quote

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Biological Activity

Importazole is a specific, cell permeable transport receptor Importin-β inhibitor that disrupts Ran GTP/importin-β interaction.
Importazole specifically blocks importin-β-mediated nuclear import both in Xenopus egg extracts and cultured cells, without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export.
Importazole impairs mitotic cargo release and disrupts mitotic spindles in cells.

Physicochemical Properties

M.Wt	318.41548
Formula	C20H22N4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	4-Quinazolinamine, N-(1-phenylethyl)-2-(1-pyrrolidinyl)-

References

1. Soderholm JF, et al. ACS Chem Biol. 2011 Jul 15;6(7):700-8.

2. Bird SL, et al. Mol Biol Cell. 2013 Aug;24(16):2506-14.

3. Bai L, et al. Cell Signal. 2014 May;26(5):857-67.

4. Yan W, et al. Cell Signal. 2015 Apr;27(4):851-9.