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Chemical Structure : Importazole
CAS No.: 662163-81-7
Catalog No.: PC-42312Not For Human Use, Lab Use Only.
Importazole is a specific, cell permeable transport receptor Importin-β inhibitor that disrupts Ran GTP/importin-β interaction.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | $258 | In stock | |
| 250 mg | Get quote |
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Importazole is a specific, cell permeable transport receptor Importin-β inhibitor that disrupts Ran GTP/importin-β interaction.
Importazole specifically blocks importin-β-mediated nuclear import both in Xenopus egg extracts and cultured cells, without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export.
Importazole impairs mitotic cargo release and disrupts mitotic spindles in cells.
| M.Wt | 318.41548 | |
| Formula | C20H22N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, N-(1-phenylethyl)-2-(1-pyrrolidinyl)- |
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1. Soderholm JF, et al. ACS Chem Biol. 2011 Jul 15;6(7):700-8.
2. Bird SL, et al. Mol Biol Cell. 2013 Aug;24(16):2506-14.
3. Bai L, et al. Cell Signal. 2014 May;26(5):857-67.
4. Yan W, et al. Cell Signal. 2015 Apr;27(4):851-9.
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