Inaxaplin (VX-147) | Apolipoprotein L1 inhibitor

Chemical Structure : Inaxaplin

CAS No.: 2446816-88-0

Inaxaplin (VX-147, VX147)

Catalog No.: PC-38400Not For Human Use, Lab Use Only.

Inaxaplin (VX-147, VX147) is a small molecule inhibitor of apolipoprotein L1 (APOL1) channel function, shows potential for treatment of proteinuric kidney disease.

Packing	Price	Stock
2 mg	$238	In stock
5 mg	$388	In stock
10 mg	$558	In stock
25 mg	$898	In stock
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Biological Activity

Inaxaplin (VX-147, VX147) is a small molecule inhibitor of apolipoprotein L1 (APOL1) channel function, shows potential for treatment of proteinuric kidney disease.

Physicochemical Properties

M.Wt	417.388
Formula	C21H18F3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl)-N-((3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl)propanamide

References

1. Patent US20210275496 A1.
2. Egbuna O, et al. N Engl J Med. 2023 Mar 16;388(11):969-979.

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Inaxaplin (VX-147, VX147)

Biological Activity

Physicochemical Properties

References

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