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Inaxaplin

Chemical Structure : Inaxaplin

CAS No.: 2446816-88-0

Inaxaplin (VX-147, VX147)

Catalog No.: PC-38400Not For Human Use, Lab Use Only.

Inaxaplin (VX-147, VX147) is a small molecule inhibitor of apolipoprotein L1 (APOL1) channel function, shows potential for treatment of proteinuric kidney disease.

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2 mg $238 In stock
5 mg $388 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Inaxaplin (VX-147, VX147) is a small molecule inhibitor of apolipoprotein L1 (APOL1) channel function, shows potential for treatment of proteinuric kidney disease.

Physicochemical Properties

M.Wt 417.388
Formula C21H18F3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl)-N-((3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl)propanamide

References

1. Patent US20210275496 A1.
2. Egbuna O, et al. N Engl J Med. 2023 Mar 16;388(11):969-979.

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