Inaxaplin (VX-147) | APOL1 inhibitor | Probechem Biochemicals

Chemical Structure : Inaxaplin

CAS No.: 2446816-88-0

Inaxaplin (VX-147, VX147)

Catalog No.: PC-38400Not For Human Use, Lab Use Only.

Inaxaplin (VX-147, VX147) is a potent small molecule inhibitor of apolipoprotein L1 (APOL1) channel with IC50 values of 2.3 nM for APOL1 G0, 1.3 nM for APOL1 G1, and 1.1 nM for APOL1 G2, inhibits APOL1-mediated flux and cell death.

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2 mg	$198	In stock
5 mg	$328	In stock
10 mg	$528	In stock
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Biological Activity

Inaxaplin (VX-147, VX147) is a potent small molecule inhibitor of apolipoprotein L1 (APOL1) channel with IC50 values of 2.3 nM for APOL1 G0, 1.3 nM for APOL1 G1, and 1.1 nM for APOL1 G2, inhibits APOL1-mediated flux and cell death.

VX-147 prevented APOL1-mediated T.b.b. death with essentially equivalent potencies to ion channel inhibition, with EC50 values of 2.0 nM for APOL1 G0, 2.1 nM for APOL1 G1, and 1.2 nM for APOL1 G2.

VX-147 inhibits APOL1-dependent cell death with EC50 values of 4.3 nM for APOL1 G0, 2.0 nM for APOL1 G1, and 2.2 nM for APOL1 G2.

VX-147 inhibits APOL1-mediated cell death and kidney damage in a transgenic mouse model.

Physicochemical Properties

M.Wt	417.388
Formula	C21H18F3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl)-N-((3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl)propanamide

References

1. Patent US20210275496 A1.
2. Egbuna O, et al. N Engl J Med. 2023 Mar 16;388(11):969-979.
3. Zimmerman B, et al. Nat Commun. 2025 Jan 2;16(1):167.

Inaxaplin (VX-147, VX147)

Biological Activity

Physicochemical Properties

References

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