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Chemical Structure : Irdabisant hydrochloride
Catalog No.: PC-61616Not For Human Use, Lab Use Only.
Irdabisant (CEP-26401) hydrochloride is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.
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Irdabisant (CEP-26401) hydrochloride is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.
Irdabisant displays >1,000-fold selectivity over the H1R, H2R, and hH4R subtypes.
Irdabisant dose-dependently inhibits H3R agonist-induced dipsogenia in the rat (ED50=0.06 mg/kg po).
Irdabisant exhibits cognition-enhancing and wake-promoting activities in mice.
| M.Wt | 349.855 | |
| Formula | C18H24ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hudkins RL, et al. J Med Chem. 2011 Jul 14;54(13):4781-92.
2. Raddatz R, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):124-33.
3. Spiegelstein O, et al. J Psychopharmacol. 2016 Oct;30(10):983-93.
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