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Chemical Structure : IsoLiPro
Catalog No.: PC-23143Not For Human Use, Lab Use Only.
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination.
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IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination.
IsoLiPro markedly reduces levels of total and phosphorylated tau in cultured cells overexpressing wild-type full-length human tau.
IsoLiPro markedly decreases USP11 protein level in SH-SY5Y cells and the mice brain.
IsoLiPro showed a strong binding affinity to USP11 (MST KD of 4.3394E-05 M), also demonstrated some extent of binding to other USPs, but the binding affinities are lower than USP11.
IsoLiPro markedly increases tau ubiquitination levels in HEK293-hTau cells.
IsoLiPro markedly induces tau clearance in the brain of 3xTg-AD and 5xFAD mice.
| M.Wt | 208.16 | |
| Formula | C9H15LiNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo Y, et al. EMBO Mol Med. 2024 Oct 11. doi: 10.1038/s44321-024-00146-7.
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