Chemical Structure : IsoLiPro
CAS No.:
IsoLiPro
Catalog No.: PC-23143Not For Human Use, Lab Use Only.
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination.
IsoLiPro markedly reduces levels of total and phosphorylated tau in cultured cells overexpressing wild-type full-length human tau.
IsoLiPro markedly decreases USP11 protein level in SH-SY5Y cells and the mice brain.
IsoLiPro showed a strong binding affinity to USP11 (MST KD of 4.3394E-05 M), also demonstrated some extent of binding to other USPs, but the binding affinities are lower than USP11.
IsoLiPro markedly increases tau ubiquitination levels in HEK293-hTau cells.
IsoLiPro markedly induces tau clearance in the brain of 3xTg-AD and 5xFAD mice.
Physicochemical Properties
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M.Wt
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208.16
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Formula
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C9H15LiNO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(O[Li]OC(C(C)C)=O)[C@H]1NCCC1
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References
1. Guo Y, et al. EMBO Mol Med. 2024 Oct 11. doi: 10.1038/s44321-024-00146-7.
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