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Chemical Structure : Ispinesib
CAS No.: 336113-53-2
Catalog No.: PC-45861Not For Human Use, Lab Use Only.
Ispinesib (SB-715992) is a potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Ispinesib (SB-715992) is a potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3 nM.
Ispinesib (SB-715992) displays >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins.
Ispinesib (SB-715992) induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death with GI50 of 20-80 nM in colon, pancreas, prostrate, and lung cancer cells.
Ispinesib (SB-715992) demonstrates tumor regression of breast cancer cell xenografts in mice at 10 mg/kg.
| M.Wt | 517.0616 | |
| Formula | C30H33ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methyl- |
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1. Good JA, et al. J Med Chem. 2013 Mar 14;56(5):1878-93.
2. Purcell JW, et al. Clin Cancer Res. 2010 Jan 15;16(2):566-76.
3. Luo L, et al. Nat Chem Biol. 2007 Nov;3(11):722-6. Epub 2007 Oct 7.
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