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Chemical Structure : Itacitinib
CAS No.: 1334298-90-6
Catalog No.: PC-45123Not For Human Use, Lab Use Only.
Itacitinib (INCB-039110) is a potent and selective, orally bioactive JAK1 inhibitor with IC50 of 2 nM, shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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Itacitinib (INCB-039110) is a potent and selective, orally bioactive JAK1 inhibitor with IC50 of 2 nM, shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively.
| M.Wt | 553.5142 | |
| Formula | C26H23F4N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
3-Azetidineacetonitrile, 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]- |
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1. Zhang Y, et al. Drug Metab Dispos. 2015 Apr;43(4):485-9.
2. Kim MK, et al. J Med Chem. 2015 Sep 24;58(18):7596-602.
3. Norman P. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
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