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Itacitinib

Chemical Structure : Itacitinib

CAS No.: 1334298-90-6

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Itacitinib (INCB-039110, INCB039110)

Catalog No.: PC-45123Not For Human Use, Lab Use Only.

Itacitinib (INCB-039110) is a potent and selective, orally bioactive JAK1 inhibitor with IC50 of 2 nM, shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively.

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5 mg $98 In stock
10 mg $148 In stock
25 mg $258 In stock
50 mg $428 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Itacitinib (INCB-039110) is a potent and selective, orally bioactive JAK1 inhibitor with IC50 of 2 nM, shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively.

Physicochemical Properties

M.Wt 553.5142
Formula C26H23F4N9O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

3-Azetidineacetonitrile, 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-

References

1. Zhang Y, et al. Drug Metab Dispos. 2015 Apr;43(4):485-9.

2. Kim MK, et al. J Med Chem. 2015 Sep 24;58(18):7596-602.

3. Norman P. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.

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