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Chemical Structure : J-2156
CAS No.: 848647-56-3
Catalog No.: PC-49080Not For Human Use, Lab Use Only.
J-2156 is a highly potent, selective somatostatin SST4 receptor agonist with binding Ki value of 1.2 nM (hSST4R), >400-fold selectivity over other human somatostatin receptor subtypes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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J-2156 is a highly potent, selective somatostatin SST4 receptor agonist with binding Ki value of 1.2 nM (hSST4R), >400-fold selectivity over other human somatostatin receptor subtypes.
J-2156 acts as a apparent full agonist by completely inhibiting the forskolin-stimulated adenylyl cyclase activity with EC50 of 70 nM.
J-2156 (1-100 microg/kg i.p.) inhibited nocifensive behaviour of mice in the second phase of the formalin test.
J-2156 inhibited sciatic nerve ligation-induced neuropathic mechanical hyperalgesia.
| M.Wt | 468.572 | |
| Formula | C24H28N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-4-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((4-methylnaphthalene)-1-sulfonamido)butanamide |
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1. Engström M, et al. J Pharmacol Exp Ther. 2005 Jan;312(1):332-8.
2. Engström M, et al. J Pharmacol Exp Ther. 2006 Mar;316(3):1262-8.
3. Sándor K, et al. Eur J Pharmacol. 2006 Jun 6;539(1-2):71-5.
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