Catalog No.: PC-49080Not For Human Use, Lab Use Only.
J-2156 is a highly potent, selective somatostatin SST4 receptor agonist with binding Ki value of 1.2 nM (hSST4R), >400-fold selectivity over other human somatostatin receptor subtypes.
J-2156 is a highly potent, selective somatostatin SST4 receptor agonist with binding Ki value of 1.2 nM (hSST4R), >400-fold selectivity over other human somatostatin receptor subtypes.
J-2156 acts as a apparent full agonist by completely inhibiting the forskolin-stimulated adenylyl cyclase activity with EC50 of 70 nM.
J-2156 (1-100 microg/kg i.p.) inhibited nocifensive behaviour of mice in the second phase of the formalin test.
J-2156 inhibited sciatic nerve ligation-induced neuropathic mechanical hyperalgesia.
