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JAK-IN-21

Chemical Structure : JAK-IN-21

CAS No.: 2445499-20-5

JAK-IN-21

Catalog No.: PC-49377Not For Human Use, Lab Use Only.

JAK-IN-21 is a selective and potent JAK inhibitor with IC50 of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAK-IN-21 is a selective and potent JAK inhibitor with IC50 of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively.

Physicochemical Properties

M.Wt 372.392
Formula C19H16N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(Cyanomethyl)-4-[2-[[1-(cyanomethyl)-1H-pyrazol-4-yl]amino]-5-methyl-4-pyrimidinyl]benzamide

References

1. Patent WO2020119819.

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