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JAK-IN-35

Chemical Structure : JAK-IN-35

CAS No.: 1400687-19-5

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JAK-IN-35 (JAK1/JAK3 inhibitor)

Catalog No.: PC-62841Not For Human Use, Lab Use Only.

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
    JAK-IN-35 shows weak activity against TYK2 and JAK2 (IC50=25 nM and15 nM respectively), also inhibits both ROCK1 (IC50=95 nM) and ROCK2 (IC50=43 nM).
    JAK-IN-35 inhibits JAK1/3 mediated ex vivo processes in the mouse PD model (EC50 67 ± 13 nM).
    JAK-IN-35 shows potential cardiovascular liabilities, specifically, QT interval prolongation.

    Physicochemical Properties

    M.Wt 408.506
    Formula C22H28N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(((1R,3S)-3-amino-2,2,3-trimethylcyclopentyl)amino)-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

    References

    1. Hynes J Jr, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106.

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