Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JAK-IN-35
Catalog No.: PC-62841Not For Human Use, Lab Use Only.
JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
JAK-IN-35 shows weak activity against TYK2 and JAK2 (IC50=25 nM and15 nM respectively), also inhibits both ROCK1 (IC50=95 nM) and ROCK2 (IC50=43 nM).
JAK-IN-35 inhibits JAK1/3 mediated ex vivo processes in the mouse PD model (EC50 67 ± 13 nM).
JAK-IN-35 shows potential cardiovascular liabilities, specifically, QT interval prolongation.
| M.Wt | 408.506 | |
| Formula | C22H28N6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Hynes J Jr, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
