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Chemical Structure : JAK-IN-35
Catalog No.: PC-62841Not For Human Use, Lab Use Only.
JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
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JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM; shows weak activity against TYK2 and JAK2 (IC50=25 nM and15 nM respectively), also inhibits both ROCK1 (IC50=95 nM) and ROCK2 (IC50=43 nM); inhibits JAK1/3 mediated ex vivo processes in the mouse PD model (EC50 67 ± 13 nM); shows potential cardiovascular liabilities, specifically, QT interval prolongation.
| M.Wt | 408.506 | |
| Formula | C22H28N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hynes J Jr, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106.
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