JAK1-IN-31 |CAS:1315498-72-6 Probechem Biochemicals

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Chemical Structure : JAK1-IN-31

JAK1-IN-31

Catalog No.: PC-63069Not For Human Use, Lab Use Only.

JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM).
JAK1-IN-31 exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model.

Physicochemical Properties

M.Wt	449.529
Formula	C23H23N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-4-(2-((R)-1-Hydroxyethyl)-6-(phenylsulfonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

References

1. Zak M, et al. J Med Chem. 2013 Jun 13;56(11):4764-85.

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JAK1-IN-31

Biological Activity

Physicochemical Properties

References

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