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Chemical Structure : JAK1-IN-31
Catalog No.: PC-63069Not For Human Use, Lab Use Only.
JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM).
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JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model.
| M.Wt | 449.529 | |
| Formula | C23H23N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zak M, et al. J Med Chem. 2013 Jun 13;56(11):4764-85.
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