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Chemical Structure : JAK2 inhibitor G5-7
CAS No.: 939681-36-4
Catalog No.: PC-35502Not For Human Use, Lab Use Only.
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2.
G5-7 demonstrates inhibitor of U87MG/EGFR and U87MG/EGFRvIII with IC50 of 0.75 and 1.0 uM, arrests cell cycle at G2 phase in both U87MG/EGFRvIII and U87MG/EGFRvIII/PTEN cells.
G5-7 significantly inhibits EGFR Tyr1068 phosphorylation but has no effect on EGFR Tyr1045 phosphorylation.
G5-7 decreases GBM tumor volume and extends the life span of tumor-bearing nude mice after oral administration.
| M.Wt | 383.395 | |
| Formula | C22H19F2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ethyl 3,5-bis((E)-2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate |
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1. He K, et al. Sci Signal. 2013 Jul 9;6(283):ra55.
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