JAK3-IN-1 |CAS:1805787-93-2 Probechem Biochemicals

Chemical Structure : JAK3-IN-1

CAS No.: 1805787-93-2

JAK3-IN-1

Catalog No.: PC-45647Not For Human Use, Lab Use Only.

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.

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10 mg	$388	In stock
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Biological Activity

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.
JAK3-IN-1 displays >150 fold selectivity versus JAK1 and JAK2.
JAK3-IN-1 exhibits decent pharmacokinetic properties and is suitable for use in vivo.

Physicochemical Properties

M.Wt	508.0151
Formula	C26H30ClN7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 47 mg/mL
Chemical Name/SMILES	2-Propenamide, N-[3-[[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-

References

1. Tan L, et al. J Med Chem. 2015 Aug 27;58(16):6589-606.

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JAK3-IN-1

Biological Activity

Physicochemical Properties

References

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