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JAK3-IN-1

Chemical Structure : JAK3-IN-1

CAS No.: 1805787-93-2

JAK3-IN-1

Catalog No.: PC-45647Not For Human Use, Lab Use Only.

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.
JAK3-IN-1 displays >150 fold selectivity versus JAK1 and JAK2.
JAK3-IN-1 exhibits decent pharmacokinetic properties and is suitable for use in vivo.

Physicochemical Properties

M.Wt 508.0151
Formula C26H30ClN7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 47 mg/mL

Chemical Name/SMILES

2-Propenamide, N-[3-[[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-

References

1. Tan L, et al. J Med Chem. 2015 Aug 27;58(16):6589-606.

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