Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-JAK/STAT Signaling-JAK-JAK3-IN-1
JAK3-IN-1

Chemical Structure : JAK3-IN-1

CAS No.: 1805787-93-2

JAK3-IN-1

Catalog No.: PC-45647Not For Human Use, Lab Use Only.

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.

Packing Price Stock Quantity
5 mg $238 In stock
10 mg $388 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.
JAK3-IN-1 displays >150 fold selectivity versus JAK1 and JAK2.
JAK3-IN-1 exhibits decent pharmacokinetic properties and is suitable for use in vivo.

Physicochemical Properties

M.Wt 508.0151
Formula C26H30ClN7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 47 mg/mL

Chemical Name/SMILES

2-Propenamide, N-[3-[[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-

References

1. Tan L, et al. J Med Chem. 2015 Aug 27;58(16):6589-606.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: