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Chemical Structure : JAK3i
CAS No.: 1918238-72-8
Catalog No.: PC-62263Not For Human Use, Lab Use Only.
JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.
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|---|---|---|---|
| 5 mg | $478 | In stock | |
| 10 mg | $728 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.
JAK3i displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively.
| M.Wt | 354.34 | |
| Formula | C18H15FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate |
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1. Smith GA, et al. Nat Chem Biol. 2016 May;12(5):373-9.
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