You are here:Home-Chemical Inhibitors & Agonists-JAK/STAT Signaling-JAK-JAK3i
JAK3i

Chemical Structure : JAK3i

CAS No.: 1918238-72-8

JAK3i (JAK3 inhibitor JAK3i)

Catalog No.: PC-62263Not For Human Use, Lab Use Only.

JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.

Packing Price Stock Quantity
5 mg $478 In stock
10 mg $728 In stock
25 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.
JAK3i displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively.

Physicochemical Properties

M.Wt 354.34
Formula C18H15FN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

References

1. Smith GA, et al. Nat Chem Biol. 2016 May;12(5):373-9.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: