JAK3i |CAS:1918238-72-8 Probechem Biochemicals

Chemical Structure : JAK3i

CAS No.: 1918238-72-8

JAK3i (JAK3 inhibitor JAK3i)

Catalog No.: PC-62263Not For Human Use, Lab Use Only.

JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.

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Biological Activity

JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.
JAK3i displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively.

Physicochemical Properties

M.Wt	354.34
Formula	C18H15FN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

References

1. Smith GA, et al. Nat Chem Biol. 2016 May;12(5):373-9.

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JAK3i (JAK3 inhibitor JAK3i)

Biological Activity

Physicochemical Properties

References

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