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JAK3 inhibitor MJ04

Chemical Structure : JAK3 inhibitor MJ04

CAS No.: 2099014-23-8

JAK3 inhibitor MJ04 (MJ04)

Catalog No.: PC-22203Not For Human Use, Lab Use Only.

JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity.
MJ04 also displays high selectivity over a panel of other kinases which include IGF1R, GSK3β, EGFR, p110α, p110β, p110γ and p110δ.
MJ04 (0.37-6 uM) significantly decreases the phosphorylation status of STAT3 at Tyr705 in A549 cells.
MJ04 (0.08mg/kg, topically applied) promotes hair regrowth in the DHT induced AGA mice model.
MJ04 dampens the naive T-cell differentiation into proinflammatory phenotypes and inhibits the proinflammatory cytokines in LPS-induced macrophages.

Physicochemical Properties

M.Wt 345.38
Formula C20H16FN5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-cyclopropyl-4-(5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine

References

1. Md Mehedi Hossain, et al. J Transl Med. 2024 Apr 18;22(1):370.

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