Chemical Structure : JAK3 inhibitor MJ04
CAS No.:
2099014-23-8
JAK3 inhibitor MJ04
(MJ04)
Catalog No.: PC-22203Not For Human Use, Lab Use Only.
JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity.
MJ04 also displays high selectivity over a panel of other kinases which include IGF1R, GSK3β, EGFR, p110α, p110β, p110γ and p110δ.
MJ04 (0.37-6 uM) significantly decreases the phosphorylation status of STAT3 at Tyr705 in A549 cells.
MJ04 (0.08mg/kg, topically applied) promotes hair regrowth in the DHT induced AGA mice model.
MJ04 dampens the naive T-cell differentiation into proinflammatory phenotypes and inhibits the proinflammatory cytokines in LPS-induced macrophages.
Physicochemical Properties
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M.Wt
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345.38
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Formula
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C20H16FN5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-cyclopropyl-4-(5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
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References
1. Md Mehedi Hossain, et al. J Transl Med. 2024 Apr 18;22(1):370.
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