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Chemical Structure : JAK3 inhibitor MJ04
Catalog No.: PC-22203Not For Human Use, Lab Use Only.
JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity.
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JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity.
MJ04 also displays high selectivity over a panel of other kinases which include IGF1R, GSK3β, EGFR, p110α, p110β, p110γ and p110δ.
MJ04 (0.37-6 uM) significantly decreases the phosphorylation status of STAT3 at Tyr705 in A549 cells.
MJ04 (0.08mg/kg, topically applied) promotes hair regrowth in the DHT induced AGA mice model.
MJ04 dampens the naive T-cell differentiation into proinflammatory phenotypes and inhibits the proinflammatory cytokines in LPS-induced macrophages.
| M.Wt | 345.38 | |
| Formula | C20H16FN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Md Mehedi Hossain, et al. J Transl Med. 2024 Apr 18;22(1):370.
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