JAK3 inhibitor RB1 | JAK3 inhibitor | Probechem Biochemicals

Chemical Structure : JAK3 inhibitor RB1

JAK3 inhibitor RB1 (RB1)

Catalog No.: PC-22202Not For Human Use, Lab Use Only.

JAK3 inhibitor RB1 is a potent, selective and irreversible JAK3 inhibitor with IC50 of 40 nM, without inhibiting JAK1, JAK2 or TYK2 (IC50>5000 nM).

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Biological Activity

JAK3 inhibitor RB1 is a potent, selective and irreversible JAK3 inhibitor with IC50 of 40 nM, without inhibiting JAK1, JAK2 or TYK2 (IC50>5000 nM).
RB1 exhibits excellent selectivity over TEC family (BMX, BTK, ITK, TXK, and TEC), the ErbB family (EGFR, ERBB4, and ERBB2), and BLK.
RB1 inhibits the phosphorylation of STAT5 elicited by IL-2 at IC50 values of 105 nM in human peripheral blood mononuclear cells (PBMCs), shows 400-fold selectivity over the IL-2 stimulated pathway.
RB1 covalently modify JAK3 Cys909 in an apparently irreversible manner.
RB1 (10 mg/kg, 30 mg/kg or 100 mg/kg) is efficacious in treating a collagen-induced arthritis model, inhibits the JAK-STAT pathway.

Physicochemical Properties

M.Wt	271.32
Formula	C14H17N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)acrylamide

References

1. Pei H, et al. Sci Rep. 2018 Mar 27;8(1):5273.

JAK3 inhibitor RB1 (RB1)

Biological Activity

Physicochemical Properties

References

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