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Chemical Structure : JAS239
Catalog No.: PC-60865Not For Human Use, Lab Use Only.
JAS239 is a carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines.
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JAS239 is a carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines.
JAS239 inhibits the phosphorylation of 14C-labeled choline in MDA-MB-231 triple-negative breast cancer cells with IC50 of 4.6 uM, significant reduces MDA-MB-231 viability with IC50 of 13.3 uM.
JAS239 is a NIR-fluorescent ChoK inhibitor.
| M.Wt | 505.099 | |
| Formula | C31H37ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arlauckas SP, et al. Mol Cancer Ther. 2014 Sep;13(9):2149-58.
2. Arlauckas SP, et al. Oncotarget. 2017 Mar 7;8(10):16518-16530.
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