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JAS239

Chemical Structure : JAS239

CAS No.: 1630288-74-2

JAS239 (JAS 239;JAS-239)

Catalog No.: PC-60865Not For Human Use, Lab Use Only.

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines; inhibits the phosphorylation of 14C-labeled choline in MDA-MB-231 triple-negative breast cancer cells with IC50 of 4.6 uM, significant reduces MDA-MB-231 viability with IC50 of 13.3 uM; a NIR-fluorescent ChoK inhibitor.

Physicochemical Properties

M.Wt 505.099
Formula C31H37ClN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(2-hydroxyethyl)-2-((1E,3E,5E)-7-((Z/E)-1-(2-hydroxyethyl)-3,3-dimethylindolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-3H-indol-1-ium chloride

References

1. Arlauckas SP, et al. Mol Cancer Ther. 2014 Sep;13(9):2149-58.

2. Arlauckas SP, et al. Oncotarget. 2017 Mar 7;8(10):16518-16530.

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