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JBSNF-000088

Chemical Structure : JBSNF-000088

CAS No.: 7150-23-4

JBSNF-000088 (JBSNF000088;6-Methoxynicotinamide)

Catalog No.: PC-63249Not For Human Use, Lab Use Only.

JBSNF-000088 (6-Methoxynicotinamide) is a small molecule nicotinamide analog that inhibits Nicotinamide N-methyltransferase (NNMT) with IC50 of 1.8, 2.8 and 5.0 µM for human, monkey and mouse NNMT, respectively.

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Biological Activity

JBSNF-000088 (6-Methoxynicotinamide) is a small molecule nicotinamide analog that inhibits Nicotinamide N-methyltransferase (NNMT) with IC50 of 1.8, 2.8 and 5.0 µM for human, monkey and mouse NNMT, respectively.
JBSNF-000088 reduces body weight, improves insulin sensitivity and normalizes glucose tolerance in mice with high fat diet (HFD)-induced obesity.
JBSNF-000088 also improves glucose handling in ob/ob and db/db mice albeit to a lesser extent and in the absence of weight loss.

Physicochemical Properties

M.Wt 152.153
Formula C7H8N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-Methoxynicotinamide

References

1. Kannt A, et al. Sci Rep. 2018 Feb 26;8(1):3660.

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