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Chemical Structure : JC-229
Catalog No.: PC-20941Not For Human Use, Lab Use Only.
JC-229 is a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1 (TbRPA1), exhibits growth inhibition of T. brucei with EC50 of 6.6 uM.
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JC-229 is a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1 (TbRPA1), exhibits growth inhibition of T. brucei with EC50 of 6.6 uM.
JC-229 (10 uM) resembles TbRPA1 depletion and has higher toxicity against T. brucei than to human cells.
JC-229 exhibited EC50 values of 6.5 µM, 18.4 µM, and 32.1 µM for T. brucei, HEK293, and HeLa, respectively.
JC-229 specifically inhibits the ssDNA-binding activity of TbRPA, strongly inhibited the binding activity of TbDBD-AB and the TbRPA complex with IC50 of 228 and 24.5 nM.
| M.Wt | 504.20 | |
| Formula | C20H14Cl4N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mukherjee A, et al. Nat Commun. 2023 Jul 20;14(1):4390.
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