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JC-229

Chemical Structure : JC-229

CAS No.:

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JC-229 (JC229)

Catalog No.: PC-20941Not For Human Use, Lab Use Only.

JC-229 is a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1 (TbRPA1), exhibits growth inhibition of T. brucei with EC50 of 6.6 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JC-229 is a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1 (TbRPA1), exhibits growth inhibition of T. brucei with EC50 of 6.6 uM.
JC-229 (10 uM) resembles TbRPA1 depletion and has higher toxicity against T. brucei than to human cells.
JC-229 exhibited EC50 values of 6.5 µM, 18.4 µM, and 32.1 µM for T. brucei, HEK293, and HeLa, respectively.
JC-229 specifically inhibits the ssDNA-binding activity of TbRPA, strongly inhibited the binding activity of TbDBD-AB and the TbRPA complex with IC50 of 228 and 24.5  nM.

Physicochemical Properties

M.Wt 504.20
Formula C20H14Cl4N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NC1=CC=C(Cl)C(Cl)=C1)C2=CC=C(C)C(S(=O)(NC3=CC=C(Cl)C(Cl)=C3)=O)=C2

References

1. Mukherjee A, et al. Nat Commun. 2023 Jul 20;14(1):4390.

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