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JC744

Chemical Structure : JC744

CAS No.: 2847094-97-5

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JC744 (JC-744)

Catalog No.: PC-25766Not For Human Use, Lab Use Only.

JC744 is a small molecule stabilizer and reactivator of p53 Y220C mutant with Kd of 320 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JC744 is a small molecule stabilizer and reactivator of p53 Y220C mutant with Kd of 320 nM.

Physicochemical Properties

M.Wt 475.28
Formula C16H15FIN3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(diethylamino)-7-(3-fluoro-1H-pyrrol-1-yl)-5-hydroxy-6-iodobenzo[d]thiazole-4-carboxylic acid

References

1. Stephenson Clarke JR, et al. ACS Pharmacol Transl Sci. 2022 Oct 11;5(11):1169-1180.

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