Catalog No.: PC-45531Not For Human Use, Lab Use Only.
JD-5037 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 2 nM, does not inhibit CB2 receptor (IC50>1000 nM).
JD-5037 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 2 nM, does not inhibit CB2 receptor (IC50>1000 nM).
JD-5037 was also characterized as an inverse agonist in forskolin-stimulated CHO cells over- expressing CB1-receptors by its ability to affect cAMP with EC50 of 46 nM.
JD-5037 showed little brain presence as indicated by tissue distribution and receptor occupancy studies.
JD-5037 (20 mg/kg PO) normalized triglyceride levels, liver mass and ALT as well a beneficial effect on glycemic control in model of diabetes.
