Catalog No.: PC-25877Not For Human Use, Lab Use Only.
JG26 is a potent, selective ADAM17 inhibitor with IC50 of IC50 of 1.9 nM, weakly inhibits ADAM-10 and MMP-2 (IC50=150 and 240 nM), does not inhibit MMP-1/9/14.
JG26 is a potent, selective ADAM17 inhibitor with IC50 of IC50 of 1.9 nM, weakly inhibits ADAM-10 and MMP-2 (IC50=150 and 240 nM), does not inhibit MMP-1/9/14. JG26 shows good inhibitory properties on sALCAM shedding in several in vitro assays. JG26 potently inhibits ADAM8 with IC50 of 12 nM. JG26 inhibits both ACE2 receptor shedding and SARS-CoV-2 infection.
