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JHU-083

Chemical Structure : JHU-083

CAS No.: 1998725-11-3

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JHU-083 (JHU083, JHU 083)

Catalog No.: PC-35603Not For Human Use, Lab Use Only.

JHU-083 is an orally available prodrug of the glutaminase inhibitor 6-diazo-5-oxo-L-norleucine (DON), blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JHU-083 (JHU083) is an orally available prodrug of the glutaminase inhibitor 6-diazo-5-oxo-L-norleucine (DON), blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

Physicochemical Properties

M.Wt 312.37
Formula C14H24N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (S)-2-((S)-2-amino-4-methylpentanamido)-6-diazo-5-oxohexanoate

References

1. Zhu X, et al. Neuropsychopharmacology. 2018 Aug 13. doi: 10.1038/s41386-018-0177-7.

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