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Chemical Structure : JHU395
CAS No.: 2079938-92-2
Catalog No.: PC-38668Not For Human Use, Lab Use Only.
JHU395 is orally-bioavailable glutamine antagonist prodrug, shows antitumor activity in malignant peripheral nerve sheath tumor (MPNST, sNF96.2 cell growth IC50=4.6 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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JHU395 is orally-bioavailable glutamine antagonist prodrug, shows antitumor activity in malignant peripheral nerve sheath tumor (MPNST, sNF96.2 cell growth IC50=4.6 uM).
JHU395 exhibits increased metabolic stability in swine and human plasma, favorable conversion in brain homogenate, and substantially improved CNS delivery in vivo in swine, compare with 6-diazo-5-oxo-L-norleucine (DON).
JHU395 attenuates glutamate synthesis in HIV-infected microglia/macrophages, offering therapeutic potential for HIV-associated neurocognitive disorders (HAND).
JHU395 also decreased growth and increased apoptosis in multiple human high-MYC medulloblastoma cell lines at lower concentrations than DON.
| M.Wt | 447.488 | |
| Formula | C22H29N3O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-Diazo-N-[[(2,2-dimethyl-1-oxopropoxy)phenylmethoxy]carbonyl]-5-oxo-L-norleucine 1-methylethyl ester |
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1. Nedelcovych MT, et al. J Med Chem. 2017;60:7186–98.
2. Lemberg KM, et al. Mol Cancer Ther. 2020 Feb;19(2):397-408.
3. Khoa Pham, et al. J Neuropathol Exp Neurol. 2021 Mar 22;80(4):336-344.
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