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Chemical Structure : JI051
CAS No.: 2234281-75-3
Catalog No.: PC-35091Not For Human Use, Lab Use Only.
JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 25 mg | $688 | In stock | |
| 100 mg | $1780 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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JI051 (JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression.
JI051 inhibits HEK293 cell proliferation with EC50 of 0.3 uM, interacts with prohibitin 2 (PHB2), stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest.
JI051 dose-dependently reduces cell growth of the human pancreatic cancer cell line MIA PaCa-2.
| M.Wt | 364.445 | |
| Formula | C22H24N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-N-(2-ethoxyphenethyl)-3-(7-methoxy-1H-indol-3-yl)acrylamide |
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1. Perron A, et al. J Biol Chem. 2018 Mar 9. pii: jbc.RA118.002316.
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