Catalog No.: PC-49293Not For Human Use, Lab Use Only.
JI130 (JI 130) is a small molecule inhibitor of the cancer-associated transcription factor Hes1, targets prohibitin 2 (PHB2) and blocks Hes1-PHB2 interaction, JI130 inhibits MIA PaCa-2 cell growth with EC50 of 49 nM.
JI130 (JI 130) is a small molecule inhibitor of the cancer-associated transcription factor Hes1, targets prohibitin 2 (PHB2) and blocks Hes1-PHB2 interaction, JI130 inhibits MIA PaCa-2 cell growth with EC50 of 49 nM.
JI130 is able to suppress cell growth in several pancreatic cancer cell lines, including CFPAC-1, PK9, and KP4-1.
JI130 inhibits tumor growth in pancreatic tumor xenograft model created with implanted MIA PaCa-2 cells.
JI130 is a JI051 derivative with improved solubility.
