Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JI130
CAS No.: 2234271-86-2
Catalog No.: PC-49293Not For Human Use, Lab Use Only.
JI130 (JI 130) is a small molecule inhibitor of the cancer-associated transcription factor Hes1, targets prohibitin 2 (PHB2) and blocks Hes1-PHB2 interaction, JI130 inhibits MIA PaCa-2 cell growth with EC50 of 49 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JI130 (JI 130) is a small molecule inhibitor of the cancer-associated transcription factor Hes1, targets prohibitin 2 (PHB2) and blocks Hes1-PHB2 interaction, JI130 inhibits MIA PaCa-2 cell growth with EC50 of 49 nM.
JI130 is able to suppress cell growth in several pancreatic cancer cell lines, including CFPAC-1, PK9, and KP4-1.
JI130 inhibits tumor growth in pancreatic tumor xenograft model created with implanted MIA PaCa-2 cells.
JI130 is a JI051 derivative with improved solubility.
| M.Wt | 376.456 | |
| Formula | C23H24N2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-N-(2-(allyloxy)phenethyl)-3-(7-methoxy-1H-indol-3-yl)acrylamide |
|
1. Perron A, et al. J Biol Chem. 2018 May 25;293(21):8285-8294.
2. Kovach AR, et al. Mol Oncol. 2022 Aug 11. doi: 10.1002/1878-0261.13304.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
