JKA3 inhibitor 31 |CAS:1637749-82-6 Probechem Biochemicals

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Chemical Structure : JKA3 inhibitor 31

JKA3 inhibitor 31 (JAK3 covalent inhibitor)

Catalog No.: PC-62261Not For Human Use, Lab Use Only.

JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases.

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Biological Activity

JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases.
JKA3 inhibitor 31 also inhibits BLK, ERB-B4 and ITK with IC50 of 22 nM, 44 nM and 221 nM, respectively.

Physicochemical Properties

M.Wt	288.31
Formula	C17H12N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(1H-indazol-4-yl)phenyl)-2-cyanoacrylamide

References

1. London N, et al. Nat Chem Biol. 2014 Dec;10(12):1066-72.

2. Clark JD, et al. J Med Chem. 2014 Jun 26;57(12):5023-38.

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JKA3 inhibitor 31 (JAK3 covalent inhibitor)

Biological Activity

Physicochemical Properties

References

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