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Chemical Structure : JKA3 inhibitor 31
Catalog No.: PC-62261Not For Human Use, Lab Use Only.
JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases.
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JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases.
JKA3 inhibitor 31 also inhibits BLK, ERB-B4 and ITK with IC50 of 22 nM, 44 nM and 221 nM, respectively.
| M.Wt | 288.31 | |
| Formula | C17H12N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. London N, et al. Nat Chem Biol. 2014 Dec;10(12):1066-72.
2. Clark JD, et al. J Med Chem. 2014 Jun 26;57(12):5023-38.
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