Chemical Structure : JM-20
CAS No.:
1789705-37-8
JM-20
Catalog No.: PC-24358Not For Human Use, Lab Use Only.
JM-20 is a benzodiazepine–dihydropyridine hybrid molecule, preventsPC-12 cell death induced either by glutamate, hydrogen peroxide or KCN-mediated chemical hypoxia, a multi-target neuroprotective agent.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JM-20 is a benzodiazepine–dihydropyridine hybrid molecule, preventsPC-12 cell death induced either by glutamate, hydrogen peroxide or KCN-mediated chemical hypoxia, a multi-target neuroprotective agent.
JM-20 protected cerebellar granule neurons from glutamate or glutamate plus pentylenetetrazole-induced damage at very low micromolar concentrations.
JM-20 prevented the Ca2+-induced mitochondrial permeability transition in rat liver mitochondria at low micromolar concentrations.
JM-20 also inhibited the mitochondrial hydrolytic activity of F1F0-ATP synthase and Ca2+ influx.
Physicochemical Properties
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M.Wt
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404.43
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Formula
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C22H20N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b] [1,5] benzodiazepine
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References
1. Nuñez-Figueredo Y, et al. Neuropharmacology. 2014 Oct;85:517-27.
2. Nuñez-Figueredo Y, et al. Eur J Pharmacol. 2014 Mar 5;726:57-65.
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