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JNJ-10229570

Chemical Structure : JNJ-10229570

CAS No.: 524923-88-4

JNJ-10229570 (JNJ10229570, JNJ 10229570)

Catalog No.: PC-35970Not For Human Use, Lab Use Only.

JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively.

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Biological Activity

JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively.
JNJ-10229570 dose dependently inhibited the production of sebaceous lipids in cultured primary human sebocytes.
Topical treatment with JNJ-10229570 of human skins transplanted onto SCID mice resulted in a marked decrease in sebum-specific lipid production, sebaceous gland's size and the expression of the sebaceous differentiation marker epithelial-membrane antigen (EMA).

Physicochemical Properties

M.Wt 389.47
Formula C22H19N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-

References

1. Eisinger M, et al. J Dermatol Sci. 2011 Jul;63(1):23-32. doi: 10.1016/j.jdermsci.2011.04.001.

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