JNJ-1953 | Orthoflavivirus NS2A inhibitor

Chemical Structure : JNJ-1953

JNJ-1953 (JNJ1953)

Catalog No.: PC-26719Not For Human Use, Lab Use Only.

JNJ-1953 is an orthoflavivirus inhibitor targeting multifunctional NS2A protein, shows nM potency against DENV-2 clinical isolates DENV-2/EDEN3295 and DENV-2/38865Y10, affects viral RNA synthesis and packaging.

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Biological Activity

Physicochemical Properties

M.Wt	567.05
Formula	C32H30ClF3N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(5R,7S,8aS)-7-((R)-(4-chlorophenyl)(2-methoxy-6-(trifluoromethyl)quinolin-3-yl)methyl)-5-phenyloctahydroindolizin-7-ol

References

1. Doortje Borrenberghs, et al. PLoS Pathog. 2026 May 5;22(5):e1014190.

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JNJ-1953 (JNJ1953)

Biological Activity

Physicochemical Properties

References

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