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Chemical Structure : JNJ-37822681
CAS No.: 935776-74-2
Catalog No.: PC-61553Not For Human Use, Lab Use Only.
JNJ-37822681 is a potent, specific and fast-dissociating dopamine D2 antagonist with Ki of 158 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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JNJ-37822681 is a potent, specific and fast-dissociating dopamine D2 antagonist with Ki of 158 nM.
JNJ-37822681 shows no significant affinity for α1, α2, H1, muscarinic, and 5-HT2C receptors, D1, D3, and 5-HT2A.
JNJ-37822681 exhibits potential therapeutic value for the treatment of schizophrenia and bipolar disorder with optimal brain disposition.
| M.Wt | 372.34 | |
| Formula | C17H17F5N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[1-[(3,4-Difluorophenyl)methyl]-4-piperidinyl]-6-(trifluoromethyl)-3-pyridazinamine |
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1. Langlois X, et al. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.
2. Schmidt ME, et al. Psychopharmacology (Berl). 2012 Dec;224(4):549-57.
3. te Beek ET, et al. J Psychopharmacol. 2012 Aug;26(8):1119-27.
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