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JNJ-37822681

Chemical Structure : JNJ-37822681

CAS No.: 935776-74-2

JNJ-37822681 (JNJ37822681)

Catalog No.: PC-61553Not For Human Use, Lab Use Only.

JNJ-37822681 is a potent, specific and fast-dissociating dopamine D2 antagonist with Ki of 158 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNJ-37822681 is a potent, specific and fast-dissociating dopamine D2 antagonist with Ki of 158 nM.
JNJ-37822681 shows no significant affinity for α1, α2, H1, muscarinic, and 5-HT2C receptors, D1, D3, and 5-HT2A.
JNJ-37822681 exhibits potential therapeutic value for the treatment of schizophrenia and bipolar disorder with optimal brain disposition.

Physicochemical Properties

M.Wt 372.34
Formula C17H17F5N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[1-[(3,4-Difluorophenyl)methyl]-4-piperidinyl]-6-(trifluoromethyl)-3-pyridazinamine

References

1. Langlois X, et al. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.

2. Schmidt ME, et al. Psychopharmacology (Berl). 2012 Dec;224(4):549-57.

3. te Beek ET, et al. J Psychopharmacol. 2012 Aug;26(8):1119-27.

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