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JNJ-40413269

Chemical Structure : JNJ-40413269

CAS No.: 1184847-16-2

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JNJ-40413269 (JNJ40413269)

Catalog No.: PC-63423Not For Human Use, Lab Use Only.

JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively.
    JNJ-40413269  exhibits a robust dose-dependent decrease in mechanical allodynia in the spinal nerve ligation model of neuropathic pain.
    JNJ-40413269 strongly raises the brain levels of AEA, PEA and OEA.

    Physicochemical Properties

    M.Wt 393.794
    Formula C19H15ClF3N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-((6-(3-chloro-4-(trifluoromethyl)phenyl)pyrimidin-4-yl)amino)-1-phenylethan-1-ol

    References

    1. Keith JM, et al. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1280-4.

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