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Chemical Structure : JNJ-40413269
Catalog No.: PC-63423Not For Human Use, Lab Use Only.
JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively.
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JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively.
JNJ-40413269 exhibits a robust dose-dependent decrease in mechanical allodynia in the spinal nerve ligation model of neuropathic pain.
JNJ-40413269 strongly raises the brain levels of AEA, PEA and OEA.
| M.Wt | 393.794 | |
| Formula | C19H15ClF3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Keith JM, et al. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1280-4.
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