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Chemical Structure : JNJ-42165279
CAS No.: 1346528-50-4
Catalog No.: PC-45666Not For Human Use, Lab Use Only.
JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $192 | In stock | |
| 50 mg | $576 | In stock | |
| 100 mg | $792 | In stock |
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JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH; no inhibition on CYPs and hERG at 10 uM; blocks FAAH in the brain and periphery of rats , causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties.
Anxiety
Phase 2 Clinical
| M.Wt | 410.8024 | |
| Formula | C18H17ClF2N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]- |
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1. Keith JM, et al. ACS Med Chem Lett. 2015 Nov 2;6(12):1204-8.
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