JNJ-46356479 | mGlu2 PAM | Probechem Biochemicals

Chemical Structure : JNJ-46356479

CAS No.: 1254979-66-2

Catalog No.: PC-27180Not For Human Use, Lab Use Only.

JNJ-46356479 is a potent and selective, orally bioavailable mGlu2 positive allosteric modulator (PAM) with EC50 of 78 nM and Emax=256%.

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10 mg	$398	In stock
25 mg	$598	In stock
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Biological Activity

JNJ-46356479 is a potent and selective, orally bioavailable mGlu2 positive allosteric modulator (PAM) with EC50 of 78 nM and Emax=256%.

M.Wt	451.45
Formula	C22H22F5N5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

1. Cid JM, et al. J Med Chem. 2016 Sep 22;59(18):8495-507.

2. Metcalf CS, et al. Epilepsia. 2018 Mar;59(3):724-735.

3. Martínez-Pinteño A, et al. Biomed Pharmacother. 2023 Feb;158:114079.