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Chemical Structure : JNJ-5207852
CAS No.: 98473-34-2
Catalog No.: PC-35408Not For Human Use, Lab Use Only.
JNJ-5207852 (JNJ5207852) is a potent, selective antagonist of H3 receptor with pKi of 8.9 and 9.24 for rat and human H3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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JNJ-5207852 (JNJ5207852) is a potent, selective antagonist of H3 receptor with pKi of 8.9 and 9.24 for rat and human H3, respectively.
JNJ-5207852 does not bind to human H1, H2 or H4 histamine receptors (pKi <5), as well as 50 GPCRs, ion channels and other drug targets.
JNJ-5207852 increases time spent awake and decreases REM sleep and slow-wave sleep in mice and rats (1-10 mg kg(-1) s.c.), ameliorates PTZ kindling-induced learning and mnemonic deficits in weanling mice.
| M.Wt | 316.489 | |
| Formula | C20H32N2O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine |
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1. Apodaca R, et al. J Med Chem. 2003 Aug 28;46(18):3938-44.
2. Barbier AJ, et al. Br J Pharmacol. 2004 Nov;143(5):649-61.
3. Jia F, et al. Neuropharmacology. 2006 Mar;50(4):404-11.
4. Abuhamdah RM, et al. Front Syst Neurosci. 2012 Jul 16;6:54.
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