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Chemical Structure : JNJ-54175446
Catalog No.: PC-61622Not For Human Use, Lab Use Only.
JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively.
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JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively; exhibits an excellent pharmacokinetic profile, good partitioning into the CNS and shows robust in vivo target engagement; orally active.
Depression
Phase 1 Clinical
| M.Wt | 438.771 | |
| Formula | C18H13ClF4N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Letavic MA, et al. J Med Chem. 2017 Jun 8;60(11):4559-4572.
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