Chemical Structure : JNJ-54175446
CAS No.:
1627902-21-9
JNJ-54175446
(JNJ54175446)
Catalog No. : PC-61622Not For Human Use, Lab Use Only.
JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively.
Packing Price Stock Quantity 1 mg $198 In stock 0 1 2 3 4 5 5 mg $398 In stock 0 1 2 3 4 5 10 mg $588 In stock 0 1 2 3 4 5 50 mg Get quote 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6162201
Biological Activity
JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively.
Physicochemical Properties
M.Wt
438.771
Formula
C18H13ClF4N6O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-1,4-dihydro-5H[1,2,3]triazolo[4,5-c]pyridin-5-yl)methanone
References
1. Letavic MA, et al. J Med Chem.
Contact Us
sales@probechem.com
