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JNJ-54175446

Chemical Structure : JNJ-54175446

CAS No.: 1627902-21-9

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JNJ-54175446 (JNJ54175446)

Catalog No.: PC-61622Not For Human Use, Lab Use Only.

JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively.
JNJ-54175446 exhibits an excellent pharmacokinetic profile, good partitioning into the CNS and shows robust in vivo target engagement; orally active.

Physicochemical Properties

M.Wt 438.771
Formula C18H13ClF4N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-1,4-dihydro-5H[1,2,3]triazolo[4,5-c]pyridin-5-yl)methanone

References

1. Letavic MA, et al. J Med Chem. 2017 Jun 8;60(11):4559-4572.

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