JNJ-54302833 | FASN inhibitor | Probechem Biochemicals

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Chemical Structure : JNJ-54302833

JNJ-54302833 (JNJ 54302833)

Catalog No.: PC-72347Not For Human Use, Lab Use Only.

JNJ-54302833 (JNJ 54302833) is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 28 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNJ-54302833 (JNJ 54302833) is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 28 nM (hFASN).
JNJ-54302833 effectively inhibits the proliferation of several cancer cell lines including ovarian, prostate, lymphoma, leukemia, lung, and breast.

Physicochemical Properties

M.Wt	493.611
Formula	C30H31N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-5-(4'-(1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)-4,6-diazaspiro[2.4]hept-4-en-7-one

References

1. Lu T, et al. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2159-2164.

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JNJ-54302833 (JNJ 54302833)

Biological Activity

Physicochemical Properties

References

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