Catalog No.: PC-23473Not For Human Use, Lab Use Only.
JNJ-7777120 (JNJ 7777120) is potent and selective histamine H4 receptor (H4R) antagonist with Ki of 4.5 nM (hH4R), >1000-fold selectivity over H1, H2, or H3 receptors.
JNJ-7777120 (JNJ 7777120) is potent and selective histamine H4 receptor (H4R) antagonist with Ki of 4.5 nM (hH4R), >1000-fold selectivity over H1, H2, or H3 receptors. JNJ-7777120 (JNJ 7777120) is equipotent against the human, mouse, and rat receptors. JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. JNJ 7777120 blocks the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model.
