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JNJ-9350

Chemical Structure : JNJ-9350

CAS No.: 326923-09-5

JNJ-9350 (JNJ9350)

Catalog No.: PC-25675Not For Human Use, Lab Use Only.

JNJ-9350 is a potent, selective Spermine oxidase (SMOX) inhibitor with IC50 of 8 nM for human SMOX (hSMOX), shows remarkable selectivity over hPAOX (>89-fold).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNJ-9350 is a potent, selective Spermine oxidase (SMOX) inhibitor with IC50 of 8 nM for human SMOX (hSMOX), shows remarkable selectivity over hPAOX (>89-fold).
JNJ-9350 displays dose-response inhibition of hSMOX cellular activity with an IC50 value of 678 nM in A549 cells.
JNJ-9350 demonstrates stabilization of hSMOX with an IC50 of 2.3 μM in cellular hSMOX engagement assays.

Physicochemical Properties

M.Wt 422.49
Formula C25H22N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-(1H-imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide

References

1. Llaveria J, et al. J Med Chem. 2025 Oct 27. doi: 10.1021/acs.jmedchem.5c01449.

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