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JNJ-A07

Chemical Structure : JNJ-A07

CAS No.: 2135640-93-4

JNJ-A07 ((+)-JNJ-A07)

Catalog No.: PC-72500Not For Human Use, Lab Use Only.

JNJ-A07 is a highly potent, highly specific dengue virus (DENV) inhibitor targeting the NS3-NS4B interaction.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNJ-A07 is a highly potent, highly specific dengue virus (DENV) inhibitor targeting the NS3-NS4B interaction.
JNJ-A07 displays high potency with nanomolar to picomolar activity against a panel of 21 clinical isolates that represent the natural genetic diversity of known genotypes and serotypes.
JNJ-A07 has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between viral proteins NS3 and NS4B.
JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models.

Physicochemical Properties

M.Wt 578.969
Formula C28H26ClF3N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO (579 mg/mL)

Chemical Name/SMILES

(+)-4-[3-[[1-(4-Chlorophenyl)-2-[2,3-dihydro-6-(trifluoromethoxy)-1H-indol-1-yl]-2-oxoethyl]amino]-5-methoxyphenoxy]butanoic acid

References

1. Suzanne J F Kaptein, et al. Nature. 2021 Oct;598(7881):504-509.

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