Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JNJ 10191584
CAS No.: 73903-17-0
Catalog No.: PC-20926Not For Human Use, Lab Use Only.
JNJ 10191584 (VUF6002) is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JNJ 10191584 (VUF6002) is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor.
JNJ 10191584 (VUF6002) shows inhibitory effects to chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively.
JNJ 10191584 (10-100 mg/kg p.o., b.i.d.) caused a dose-dependent reduction in macroscopic damage, inhibition of the TNBS-provoked elevation of both colonic myeloperoxidase and tumour necrosis factor-alpha (TNF-alpha), and a reduction in the histologically assessed increase in mucosal and submucosal thickness and neutrophil infiltration.
| M.Wt | 278.74 | |
| Formula | C13H15ClN4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(5-chloro-1H-benzo[d]imidazol-2-yl)(4-methylpiperazin-1-yl)methanone |
|
1. Varga C, et al. Eur J Pharmacol. 2005 Oct 17;522(1-3):130-8.
2. Venable JD, et al. J Med Chem. 2005 Dec 29;48(26):8289-98.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
