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Chemical Structure : JNJ 10191584 maleate
Catalog No.: PC-20925Not For Human Use, Lab Use Only.
JNJ-10191584 (VUF6002) maleate is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor.
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JNJ-10191584 (VUF6002) maleate is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor.
JNJ-10191584 (VUF6002) shows inhibitory effects to chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively.
JNJ 10191584 (10-100 mg/kg p.o., b.i.d.) caused a dose-dependent reduction in macroscopic damage, inhibition of the TNBS-provoked elevation of both colonic myeloperoxidase and tumour necrosis factor-alpha (TNF-alpha), and a reduction in the histologically assessed increase in mucosal and submucosal thickness and neutrophil infiltration.
| M.Wt | 394.81 | |
| Formula | C17H19ClN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Varga C, et al. Eur J Pharmacol. 2005 Oct 17;522(1-3):130-8.
2. Venable JD, et al. J Med Chem. 2005 Dec 29;48(26):8289-98.
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