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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-TRP Channel-JNc-440
JNc-440

Chemical Structure : JNc-440

CAS No.: 1119503-63-7

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JNc-440 (JNc440)

Catalog No.: PC-61767Not For Human Use, Lab Use Only.

JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3.

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5 mg $48 In stock
10 mg $68 In stock
25 mg $118 In stock
50 mg $188 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3.
JNc-440 shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.

Physicochemical Properties

M.Wt 440.503
Formula C26H24N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(2,2-diphenylacetamido)propyl)-4-oxo-1,4-dihydroquinazoline-2-carboxamide

References

1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725.

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