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Chemical Structure : JNc-440
Catalog No.: PC-61767Not For Human Use, Lab Use Only.
JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3.
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JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3.
JNc-440 shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.
| M.Wt | 440.503 | |
| Formula | C26H24N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725.
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