Chemical Structure : JQ1
CAS No.:
1268524-70-4
JQ1
(JQ-1;(+)-JQ-1)
Catalog No. : PC-43338Not For Human Use, Lab Use Only.
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.
Packing Price Stock Quantity 25 mg $158 In stock 0 1 2 3 4 5 100 mg $358 In stock 0 1 2 3 4 5 500 mg $1058 In stock 0 1 2 3 4 5 1 g $1680 In stock 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4333801
Biological Activity
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively; induces rapid expression of keratin in treated NMC 797 cells, displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.
Physicochemical Properties
M.Wt
456.9882
Formula
C23H25ClN4O2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 45 mg/mL
Chemical Name/SMILES
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
References
1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.
2. Matzuk MM, et al. Cell. 2012 Aug 17;150(4):673-84.
3. Peirs S, et al. Leukemia. 2017 Oct;31(10):2037-2047.
4. Tögel L, et al. Mol Cancer Ther. 2016 Jun;15(6):1217-26.
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