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JT001

Chemical Structure : JT001

CAS No.:

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JT001 (JT-001)

Catalog No.: PC-20912Not For Human Use, Lab Use Only.

JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly.
JT001 potently and selectively inhibited NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis, a form of inflammatory cell death triggered by active caspase-1, in cell-based assays.
Orally administered JT001 was effective in reducing hepatic inflammation in three different murine models, including the Nlrp3A350V/+CreT model of Muckle-Wells syndrome (MWS), a diet-induced obesity NASH model, and a choline-deficient diet-induced NASH model.

Physicochemical Properties

M.Wt 246.24
Formula C7H10N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(N)NS(=O)(C1=C2OCCCN2N=C1)=O

References

1. Povero D, et al. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258.

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