Chemical Structure : JTE907
CAS No.: 282089-49-0
Catalog No.: PC-60763Not For Human Use, Lab Use Only.
JTE907 (JTE-907) is a potent, selective, orally active cannabinoid CB2 receptor inverse agonist with Ki of 35.9, 1.55 and 0.38 nM for human, mouse and rat CB2, respectively.
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JTE907 (JTE-907) is a potent, selective, orally active cannabinoid CB2 receptor inverse agonist with Ki of 35.9, 1.55 and 0.38 nM for human, mouse and rat CB2, respectively.
JTE907 increases of forskolin-stimulated cAMP production in CHO cells expressing CB2 in vitro, inhibits carrageenin-induced mouse paw edema dose dependently in mice.
M.Wt | 438.48 | |
Formula | C24H26N2O6 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide |
1. Iwamura H, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):420-5.
2. Ueda Y, et al. Eur J Pharmacol. 2005 Sep 27;520(1-3):164-71.
3. Maekawa T, et al. Eur J Pharmacol. 2006 Aug 7;542(1-3):179-83.
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