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JTE907

Chemical Structure : JTE907

CAS No.: 282089-49-0

JTE907 (JTE-907;JTE 907)

Catalog No.: PC-60763Not For Human Use, Lab Use Only.

JTE907 (JTE-907) is a potent, selective, orally active cannabinoid CB2 receptor inverse agonist with Ki of 35.9, 1.55 and 0.38 nM for human, mouse and rat CB2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JTE907 (JTE-907) is a potent, selective, orally active cannabinoid CB2 receptor inverse agonist with Ki of 35.9, 1.55 and 0.38 nM for human, mouse and rat CB2, respectively.
JTE907 increases of forskolin-stimulated cAMP production in CHO cells expressing CB2 in vitro, inhibits carrageenin-induced mouse paw edema dose dependently in mice.

Physicochemical Properties

M.Wt 438.48
Formula C24H26N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide

References

1. Iwamura H, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):420-5.

2. Ueda Y, et al. Eur J Pharmacol. 2005 Sep 27;520(1-3):164-71.

3. Maekawa T, et al. Eur J Pharmacol. 2006 Aug 7;542(1-3):179-83.

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